Disruptive Technology
The Endo Bi-ME® system utilizes a blend of solutions which are optimized not only to:
• Eliminate residual root canal biofilm
• Strengthen the remaining root dentin
• Regulate the biological process of periapical healing
• Support three-dimensional root filling in minimally prepared small and large canals.
Designed to be an effective antibiofilm strategy in the complex root canals spaces.
Light activated singlet oxygen derived antibiofilm strategy in the complex root canal system.
The Endo Bi-ME® handpiece utilizes an S-shaped tip and a Tapered tip to agitate solutions in the root canal or a tapered tip for light transmission only.
The transparent S-shaped tip and Tapered tip allow light emitted at the head of the handpiece to be conducted into the pulp chamber and root canal system to activate the proprietary Endo Bi-ME® solutions and enhance the effectiveness of these solutions.
S-shaped Tip
The curved tip agitates the microbubble solutions creating shear forces on the wall of the root canal facilitating the removal of biofilms and smear layer whilst creating a viscous-dominant flow for the microbubbles to interact with the complexities of the root canal system.
Tapered Tip
The tapered tip effectively conducts the green light to the apex activating the bioactive portion of the propriety Endo-BiMe solution which facilitates dentin strengthening, periapical healing and sealing ability of the root canal biosealers.
We apply our knowledge and high-end technology to dentin preservation achieved through:
• Activated microbubble-based root canal disinfection
• Innovative bioactive material-based tooth strengthening strategy
• Complete innovation in root canal therapy
SyAct® International is progressively improving the dental experience for patients and clinicians. It is committed to delivering predictable outcomes and offering patient experience that ensures minimally invasive procedures and remarkably rapid healing to maintain healthy and functional teeth.
Translate basic science to clinical applications that benefits patient care.
We are a research-based corporation dedicated to delivering smart, cutting-edge solutions to achieve optimal results in dental practice. We work together with other professionals to develop new technology that will be instrumental in the future of healing. We lead the way to higher standards in dentistry, medicine and veterinary sciences.
Dr. Sergio Kuttler received his Dental Degree in 1978, from the Universidad Tecnologica De Mexico, in Mexico City, Mexico.
He was in practice of General and Pediatric Dentistry for several years; in 1984 Dr. Kuttler received his Endodontic Certificate from the University of Southern California.
He has been involved in academics since his graduation from USC and practicing exclusively Endodontics.
His major areas of scientific research interest include the performance of nickel-titanium endodontic instruments, three dimensional obturation of the root canal space evaluated with micro and nano CT; root canal irrigation and restoring endodontically treated teeth.
Dr. Anil Kishen is a Professor and Dr. Lloyd & Mrs. Kay Chapman Chair in Clinical Sciences at the Faculty of Dentistry, University of Toronto, Canada. He is also cross-appointed as an Associate Scientist in the Department of Dentistry at Mount Sinai Hospital, Toronto, Canada. Dr. Kishen has received several awards and honors, including The Enterprise Challenge Innovator for an innovative proposal that substantially improved public service delivery in Singapore and the W. W. Wood Award (2016) for excellence in Dental Education from the Association of Canadian Faculties of Dentistry.
View MoreBachelor of Dental Surgery degree in 2003, from Dr. MGR medical university in Chennai India and subsequently got his Masters in Dental Surgery (Endodontics) from the Faculty of Dentistry, The University of Hong Kong in 2006. He is currently a Clinical Assistant Professor (Endodontics) in the Faculty of Dentistry, The University of Hong Kong where he is the Undergraduate Program Director for the endodontic discipline.
View MoreFull-time assistant professor and principal investigator in the Faculty of Dentistry, University of Toronto. She is cross appointed in Laboratory Medicine and Pathobiology, University of Toronto and Department of Dentistry at the Mt. Sinai Hospital, Toronto.
View MoreDental degree from the University of Maryland School of Dentistry, and his Certificate in Endodontics from The Albert Einstein Medical Center. He is Clinical Associate Professor of Endodontics at the University of Maryland School of Dentistry, a Clinical Instructor and Guest Lecturer at The Albert Einstein Medical Center, and Resident Faculty at Spear Education.
View MoreDr. Alice (Fang-Chi) Li currently works as an associate at Davisville Endodontics and Toronto Dental Specialists. She also holds the positions of adjunct professor and clinical instructor at the University of Toronto, Faculty of Dentistry. She is a Diplomate of the American Board of Endodontics.
View MoreReceived his DDS in 1985 from the Collage of Dentistry, Cairo University. Dr. Fayad received his Master’s in Oral Sciences in 1994 from the University of Buffalo at NewYork. He received his PhD in 1996 as a joint supervision between University of Buffalo at New York and Cairo University.
View MoreProfessor Emeritus in Endodontics/Restorative Sciences, Texas A&M University College of Dentistry, Dallas, Texas. Dr. Gutmann is a Diplomate of the American Board of Endodontics, Past President of the American Association of Endodontists, Past President of the American Academy of the History of Dentistry, and the present Editor of the Journal of the History of Dentistry.
View MoreDental Degree in 1978, from the Universidad Tecnologica De Mexico, in Mexico City, Mexico. in 1980 Dr. Kogan received his Fixed Prosthodontics Certificate from the University Of Missouri – Kansas City. He has been involved in academics since his graduation from UMKC and practicing exclusively Restorative Dentistry.
View MoreDr. Sergio Kuttler received his Dental Degree in 1978 from the Universidad Tecnologica De Mexico in Mexico City, Mexico.
He was in General and Pediatric Dentistry practice for several years; in 1984, Dr. Kuttler received his Endodontic Certificate from the University of Southern California. He has been involved in academics since graduating from USC and practicing exclusively in endodontics. His primary areas of scientific research interest include the performance of nickel-titanium endodontic instruments, three-dimensional obturation of the root canal space evaluated with micro and nano CT, root canal irrigation, and restoring endodontically treated teeth.
Dr. Kuttler is a co-inventor of WaveOne, Reciproc, WaveOne Gold and WaveOne Gold Glider, SyAct Irrigation System, and ProSafe Post. Dr. Kuttler is a world-renowned endodontist and internationally recognized lecturer. He has presented over 730 national and worldwide courses and lectures in over 60 cities of 47 countries throughout six continents. He is the author/coauthor of 34 scientific papers published in peer-reviewed journals and other world-recognized publications and a contributor author in six endodontic textbooks. He serves/served on several editorial boards of journals (Journal Of Endodontics, Endodontic Topics, Endodontic Practice (US), ROOTS, Endo Tribune, Journal Of The Mexican Dental Association, Clinical Oral Investigations, Restorative Dentistry & Endodontics).
Dr. Kuttler is the former founding Chair and Postgraduate Program Director at the Universidad Tecnologica De Mexico, Mexico City, Mexico; Dr. Kuttler is the former Chair of the Endodontic Department and Associate Dean For Advanced Education Programs at Nova Southeastern University, College Of Dental Medicine in Fort Lauderdale, Florida. Now, Dr. Kuttler is the Founder of the International Endodontic Institute (IEI) in Fort Lauderdale, Florida, USA; Dr. Sergio Kuttler is one of the co-inventors with Dr. Anil Kishen and Dr. Jeffrey Chang of SyAct Irrigation System.
Dr. Anil Kishen is a Professor and Dr. Lloyd & Mrs. Kay Chapman Chair in Clinical Sciences at the Faculty of Dentistry, University of Toronto, Canada. He is also cross-appointed as an Associate Scientist in the Department of Dentistry at Mount Sinai Hospital, Toronto, Canada. Dr. Kishen has received several awards and honors, including The Enterprise Challenge Innovator for an innovative proposal that substantially improved public service delivery in Singapore and the W. W. Wood Award (2016) for excellence in Dental Education from the Association of Canadian Faculties of Dentistry. The prestigious Louis I. Grossman Award (2021) from the American Association of Endodontists for the cumulative publication of significant research studies that have made an extraordinary contribution to endodontology. And the National Dental Research Award (2023) from the Canadian Association for Dental Research (CADR) and the Association of Canadian Faculties of Dentistry (ACFD) for exceptional contributions to dental research in a Canadian University. Dr. Kishen’s research focuses on microbe-host cell interactions, cellular crosstalk in wound healing and nanoparticle-guided tissue engineering.
BDS (India), MFDS RCS(Glasgow), MDS (Endo) (HK)
Dr. Chang Wen Wei Jeffrey received his Bachelor of Dental Surgery degree in 2003, from Dr. MGR medical university in Chennai India and subsequently got his Masters in Dental Surgery (Endodontics) from the Faculty of Dentistry, The University of Hong Kong in 2006. He is currently a Clinical Assistant Professor (Endodontics) in the Faculty of Dentistry, The University of Hong Kong where he is the Undergraduate Program Director for the endodontic discipline.
He also co-supervises post-graduate clinical teaching and research activities within the faculty and runs a referral based private practice in central Hong Kong. His research interests lie in the restoration of endodontically treated teeth, endodontic instrumentation & disinfection and endodontic pedagogy and has published as a primary and co-author in peer reviewed journals and conducted numerous lectures and hands-on across the Asian region.
Dr. Annie Shrestha is a full-time assistant professor and principal investigator in the Faculty of Dentistry, University of Toronto. She is cross appointed in Laboratory Medicine and Pathobiology, University of Toronto and Department of Dentistry at the Mt. Sinai Hospital, Toronto. Dr. Shrestha obtained her dental degree from Nepal (2005), M.Sc. research from Singapore (2009), and Ph.D. in Nanobiomaterials (2013) and M.Sc. (Endodontics) (2017) from the University of Toronto.
She is a clinician scientist, teaches undergraduate and graduate dental students. She maintains an independent laboratory with research focus on role of immune cells in apical periodontitis pathogenesis and healing complicated with metabolic diseases. Her research expertise encompasses immune dysbiosis in chronic oral infections and metabolic disease; cell mechanosensing; nano/biomaterials and 3D hydrogels for cell modulation. Further she focuses to expand on immunomodulation by utilizing biomaterials to achieve better therapeutics for the treatment of chronic oral infections.
Her lab is funded by several independent grants. She has published over 30 peer-reviewed journal papers, 5 book chapters and presented over 30 research and invited presentations in international forum. She currently serves as the Chair of the AAE Regenerative Endodontics Committee, scientific advisory board of the Journal of Endodontics, Frontiers in Dentistry and Associate Editor of the Restorative Dentistry and Endodontics.
Dr. Berman received his dental degree from the University of Maryland School of Dentistry, and his Certificate in Endodontics from The Albert Einstein Medical Center. He is Clinical Associate Professor of Endodontics at the University of Maryland School of Dentistry, a Clinical Instructor and Guest Lecturer at The Albert Einstein Medical Center, and Resident Faculty at Spear Education. He has lectured internationally in the field of endodontics and has published in several peer reviewed international dental journals as well as co-authoring textbook chapters on numerous topics in various endodontic textbooks. He is past president of the Maryland State Association of Endodontics and is a member of the Journal of Endodontics Scientific Advisory Board. Dr. Berman is the co-author of the chapter on Diagnosis and the chapter on Root Fractures in Cohen’s Pathways of the Pulp, where he is the co-editor with Dr. Kenneth Hargreaves. He is also the senior editor and contributing author of the comprehensive textbook, Dental Traumatology. He is the President and Founder of Berman Dental Instruments. A board certified endodontist and Fellow of the American College of Dentistry, Dr. Berman has been in full time private practice in Annapolis, Maryland for the past forty years.
Dr. Alice (Fang-Chi) Li currently works as an associate at Davisville Endodontics and Toronto Dental Specialists. She also holds the positions of adjunct professor and clinical instructor at the University of Toronto, Faculty of Dentistry. She is a Diplomate of the American Board of Endodontics.
Dr. Li obtained her Ph.D. and M.Sc. (Endodontics) from the University of Toronto. She worked on researches of improving the biomechanical properties and fatigue resistance of endodontically treated dentin using engineered bioactive nanoparticles; and developing a 3D organoid model to study the cell signaling mechanism associated with regenerative endodontics. She has published many articles in peer-reviewed journals and received numerous international and national awards in the field of endodontics from the American Association of Endodontists, Journal of Endodontics and the Canadian Association for Dental Research. Dr. Li continues her research and teaching at the University of Toronto Faculty of
Dentistry, serves as a scientific advisory board member of peer-reviewed journals, as well as enjoys being an endodontist working in Toronto.
Dr. Fayad received his DDS in 1985 from the Collage of Dentistry, Cairo University. Dr. Fayad received his Master’s in Oral Sciences in 1994 from the University of Buffalo at NewYork. He received his PhD in 1996 as a joint supervision between University of Buffalo at New York and Cairo University. He received his Endodontic training at the college of Dentistry at UIC. Currently he is the director of endodontic research, and a clinical associate professor in the Endodontic department at College of Dentistry at UIC, dividing his time between teaching, research, intra-and extra-mural continuing education and private practice. He currently serves on the Scientific Advisory and Manuscript Review Panels of the Journal of Endodontics, and Evidence Based Endodontics Journal. He served on the AAE Research and Scientific Affairs Committee and co-chaired AAE/AAOMR committee drafting the joint position statement on CBCT (2015). He has numerous publications and chapters in peer reviewed journals and textbooks (Pathways of the pulp, Contemporary surgical Endodontics, and Endodontics Principles and Practice). He is the co-editor of the CBCT text book (3-D Imaging in Endodontics: A new Era in diagnosis and treatment) by Springer (2016 and 2023). He is a recipient of the Calvin D. Torneck Part-Time Educator Award for 2022 by the American Association of Endodontists. He is a Diplomate of the American Board of Endodontics and gave numerous presentations nationally and internationally.
Dr. James L. Gutmann is Professor Emeritus in Endodontics/Restorative Sciences, Texas A&M University College of Dentistry, Dallas, Texas. Dr. Gutmann is a Diplomate of the American Board of Endodontics, Past President of the American Association of Endodontists, Past President of the American Academy of the History of Dentistry, and the present Editor of the Journal of the History of Dentistry. He is the recipient of the IB Bender Award for Lifetime Educator Award, the Edgar D. Coolidge Award, the highest honor bestowed by the AAE and will receive the Ralph F. Sommer Award in 2024. He has presented over 850 lectures, papers, and continuing education courses in the United States and 54 foreign countries. Additionally, he has authored or co-authored over 400 articles in dental journals that address scientific, research, educational, historical, and clinical topics and 3 textbooks. He has taught full time for over 30 years at four major universities, in addition to practicing his specialty over 50 years.
Dr. Enrique Kogan received his Dental Degree in 1978, from the Universidad Tecnologica De Mexico, in Mexico City, Mexico. in 1980 Dr. Kogan received his Fixed Prosthodontics Certificate from the University Of Missouri – Kansas City. He has been involved in academics since his graduation from UMKC and practicing exclusively Restorative Dentistry. His major areas of scientific research interest include restoring endodontically treated teeth, evolution of bonding materials, accurate color in fixed prosthodontics.
Dr. Kogan is the inventor of the Peerless Post and ProSafe Post. Dr. Kogan is a world-renowned prosthodontists and internationally recognized lecturer, he has presented over 150 worldwide courses and lectures. He is the author/coauthor of 20 scientific papers published in peer-reviewed journals and other world recognized publications, and contributor author in two prosthodontics textbooks.
Dr. Kogan is the former Chair and Postgraduate Program Director at the Universidad Tecnologica de Mexico, Mexico City, Mexico, Visiting Professor at Nova Southeastern University, College Of Dental Medicine in Fort Lauderdale, Florida, United States, Visiting Professor Universidad Intercontinental in Mexico City, Mexico.
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